Wales prop Nicky Smith faces up to four months on the sidelines because of injury.
South Africa have made five changes from the 22-6 victory over Italy last weekend for their clash with Wales on Saturday.
England assistant coach Graham Rowntree says Australia captain Michael Hooper will receive "special attention" on Saturday.
Sam Burgess may make a surprise debut for Bath this Friday, just weeks after fracturing his cheekbone and eye socket.
England have named an unchanged matchday squad for Saturday's final QBE International against Australia at Twickenham.
Our betting blog has reaction to Manchester City's victory over Bayern plus build-up to tonight's Champions League games.
Ireland flanker Chris Henry has undergone a procedure to repair a heart defect.
Blair Cowan has signed a new long-term contract with London Irish that will keep him with the club until 2018.
Shaun Edwards has hit back angrily at the suggestion that Wales head coach Warren Gatland is under pressure.
Graham Rowntree is braced for set-piece chicanery from Australia when England host the Wallabies on Saturday.